BICM – Biochemistry
Biochemistry is the study of the chemistry of life. This course introduces students to the complexities of the cellular environment and its impact on the chemical reactions that occur in the cell. Structural and functional aspects of proteins (both enzymatic and non-enzymatic) and nucleic acids are examined. The course also introduces intermediary metabolism, focusing on carbohydrate metabolism. Emphasis is on free energy changes associated with these processes, and their regulation and integration.
This course explores the principles of intermediary metabolism, the chemical reactions by which organisms store and generate energy required for life. Topics include bioenergetics, as well as molecular mechanisms of regulation and integration of carbohydrate, lipid, and amino acid metabolism. Selected examples are used to illustrate how imbalances in the metabolic pathways can lead to disease.
Structure and Function of Biomolecules
This course illustrates the relationship between structure and function in biological molecules. The structure of proteins is discussed with selected examples to illustrate protein function. Mechanisms of enzymatic catalysis are presented with an emphasis on kinetics and regulatory mechanisms. Structural and functional aspects of carbohydrates and lipids are presented, with reference to glycobiology, biological membranes and mechanisms of transport. Experimental methods used to study proteins, carbohydrates and lipids are introduced.
Nucleic Acid Biochemistry
This course provides a comprehensive examination of the biochemistry of nucleic acids. The structure, function and metabolism of nucleotides are explored. Nucleic acids and chromosomes are examined at their structural level. The molecular mechanisms of both DNA and RNA metabolism are discussed with particular attention to replication, DNA repair, recombination, transcription, reverse transcription and translation. The diverse roles of RNA are explored, including catalysis, regulation and molecular recognition. A variety of applications of DNA- and RNA-based technologies are discussed.