BICM – Biochemistry
Biochemistry is the study of the chemistry of life. This course introduces students to the complexities of the cellular environment and its impact on the chemical reactions that occur in the cell. Structural and functional aspects of proteins and nucleic acids are examined. The course also introduces intermediary metabolism, focusing on carbohydrate metabolism. Emphasis is on the free energy changes that govern metabolic pathways, and their regulation and integration.
This course explores the principles of intermediary metabolism, the chemical reactions by which organisms store and generate energy required for life. Topics include bioenergetics, as well as molecular mechanisms of regulation and integration of carbohydrate and lipid metabolism. Selected examples are used to illustrate how imbalances in metabolic pathways can lead to disease.
Structure and Function of Biomolecules
This course explores the relationship between structure and function including proteins, carbohydrates, and lipids. Mechanisms of enzymatic catalysis are analyzed with an emphasis on kinetics and regulatory mechanisms. The rich structural and functional variety of carbohydrates and lipids is presented, with reference to glycobiology, biological membranes and mechanisms of transport. Students are introduced to experimental methods used to study proteins, carbohydrates and lipids.
Nucleic Acid Biochemistry
This course examines the structure, function and metabolism of nucleic acids. Diseases that result from defects in nucleic acid biochemistry are explored. We discuss the chemical logic and molecular mechanisms of DNA and RNA metabolism with particular attention to replication, DNA repair, recombination, transcription, reverse transcription and translation. The diverse roles of RNA are explored, including catalysis, regulation and molecular recognition. A variety of applications of DNA- and RNA-based technologies are discussed.